US EditionFDA Approves First Daily Pill for Weight Loss Treatment
The FDA approved the first daily oral GLP-1 drug for weight management, showing about 16.6% average weight loss in trials, expanding options beyond injections.
- On Dec. 22, 2025 the U.S. Food and Drug Administration approved a pill version of Wegovy, Novo Nordisk A/S's first oral GLP-1 therapy cleared for weight management in the United States.
- In the 64-week OASIS 4 trial, 307 adult participants randomized to oral semaglutide 25 mg showed mean weight loss of about 17% when treatment was adhered to.
- Among trial participants, 76% achieved at least 5% weight loss; a 1.5 mg starting dose will be available in early January for $149 per month, and production is underway at Novo Nordisk North Carolina manufacturing sites.
- Novo Nordisk plans a U.S. launch in early January 2026, including an indication to reduce major adverse cardiovascular events, while pricing and demand remain key market factors.
- Facing competition from Eli Lilly, Novo Nordisk struggles to regain share as more patients choose Zepbound, while it argues a convenient GLP-1 pill without cold storage could boost interest but unclear if market share will rise.
348 Articles
348 Articles
Wegovy is coming in pill form. Here’s when, how much, and how well it works
People who are squeamish about needles will soon have an alternative, as the Food and Drug Administration has approved a pill version of Wegovy that could be available as soon as next month. Novo Nordisk, maker of the GLP-1 weight-loss drug, announced on Monday that it has received FDA approval for its once-daily pill that has been shown to achieve comparable weight-loss results as the injectable Wegovy. The Danish drugmaker said the pill could …
Novo Nordisk’s Wegovy Pill Becomes First FDA-Approved Oral GLP-1 Drug for Weight Loss
Beyond weight reduction and long-term maintenance of weight loss, the FDA decision for oral Wegovy covers use of the once-daily pill for reducing the risk of major cardiovascular events. Novo Nordisk expects the Wegovy tablet will launch in early January. The post Novo Nordisk’s Wegovy Pill Becomes First FDA-Approved Oral GLP-1 Drug for Weight Loss appeared first on MedCity News.
Novo Nordisk Strikes First With Oral Wegovy -- But Can It Outrun Lilly's Looming Pill?
Yesterday, the Food and Drug Administration (FDA) approved Novo Nordisk‘s (NYSE:NVO) Wegovy weight-loss pill, the first of its kind. This once-daily tablet uses the same active ingredient — semaglutide — as the injectable Wegovy and Ozempic, but in a higher 25 mg dose to achieve comparable efficacy despite lower absorption because it is taken orally. ... Novo Nordisk Strikes First With Oral Wegovy — But Can It Outrun Lilly’s Looming Pill?
The U.S. Food and Drug Administration (FDA) has approved a tablet version of its weight-loss drug Wegovy, according to pharmaceutical giant Novo Nordisk. It is the first such tablet to receive regulatory approval and could usher in a new era in the history of weight-loss drugs. Wegovy's Danish maker, Novo Nordisk, said the once-daily tablet is a "convenient alternative" to the weekly injectable drug and produces the same weight loss. The approva…
The U.S. Food and Drug Administration Agency has approved the use in pill form of Wegovy slimming drug from the pharmaceutical company...
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