Novel radiotherapy target definition using AI-driven predictions of glioblastoma recurrence from metabolic and diffusion MRI

Novel radiotherapy target definition using AI-driven predictions of glioblastoma recurrence from metabolic and diffusion MRI

The current standard-of-care (SOC) practice for defining the clinical target volume (CTV) for radiation therapy (RT) in patients with glioblastoma still employs an isotropic 1–2 cm expansion of the T2-hyperintensity lesion, without considering the heterogeneous infiltrative nature of these tumors. This study aims to improve RT CTV definition in patients with glioblastoma by incorporating biologically relevant metabolic and physiologic imaging ac…