T Cells Take up Residence in the Healthy Brain via a Gut-Fat-Brain Axis

T cells take up residence in the healthy brain via a gut-fat-brain axis

The brain is a unique place. It is shielded from much of the body by the blood-brain barrier, meaning it's protected from pathogens and potentially dangerous substances that might be in our blood. And historically, many scientists believed that separation extended to the immune system as well: the brain has its own specialized immune cells called microglia, but immune cells present in the rest of the body were long thought to steer clear of the …

Yale Researchers Identify Gut-Linked Immune Cells in the Brain

Yale School of Medicine researchers have discovered, for the first time, specialized immune cells in the brains of mice and humans which may facilitate communication between the gut and brain.

T Cells Take Up Residence in the Healthy Brain Via a Gut-Fat-Brain Axis

The brain is a unique place. It is shielded from much of the body by the blood-brain barrier, meaning it's protected from pathogens and potentially dangerous substances that might be in our blood.

Newly Discovered T Cells in Brain Originate in the Gut

Newswise — NEW HAVEN, Conn., May 28, 2025 -- Yale School of Medicine researchers have discovered, for the first time, specialized immune cells in the brains of mice and humans which may facilitate communication between the gut and brain. In a study published May 28 in Nature, a team led by Tomomi Yoshida, PhD candidate in the Department of Immunobiology, found never-before-seen CD4 T cells in healthy brains. The cells shared more characteristics…