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Scientists Link Brain Lithium Loss to Early Alzheimer’s Changes

BOSTON, MASSACHUSETTS AND CHICAGO, ILLINOIS, AUG 8 – Researchers reveal lithium orotate may reverse memory loss and brain damage linked to Alzheimer’s, with studies showing low lithium levels contribute to cognitive decline, Nature reports.

Summary by News Medical
Researchers have discovered that naturally occurring lithium in the brain is depleted early in Alzheimer’s disease, especially in the prefrontal cortex, and that restoring physiological levels with lithium orotate in mice can prevent brain damage and memory loss. The findings suggest lithium deficiency may be a modifiable risk factor for Alzheimer’s.

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Lithium is best known in medicine as a mood stabilizer given to people with bipolar disorder and depression.

A team from Harvard University (USA) has tested the link between lithium and alzhéimer and the health of the brain, in general, in mice. They have also seen levels of this substance drop dramatically between people with signs of dementia. Does this mean that the alzhéimer is caused by a lack of lithium? Is lack of lithium a consequence? Or is it another factor? What is known. Alzhéimer is characterized by the accumulation of ovules and plates of…

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WWL broke the news in on Thursday, August 7, 2025.
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