New Form of Cell Death Discovered in Alzheimer’s

New Karyoptosis Mechanism Linked to Alzheimer's and Frontotemporal Dementia

Markers of a new mechanism for cell death, called karyoptosis, have been found in brains of patients with Alzheimer's disease and frontotemporal dementia (FTD).

New mechanism found for neuronal death in Alzheimer’s and frontotemporal dementia

Markers of a new mechanism for cell death, called karyoptosis, have been found in brains of patients with Alzheimer’s disease and frontotemporal dementia (FTD). In many neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s and FTD, toxic levels of proteins accumulate inside neurons, which subsequently die. While there are other known forms of cell death, such as apoptosis, they do not account for all neuronal loss i…

New Form of Cell Death Discovered in Alzheimer’s

Researchers identified a new form of programmed cell death called karyoptosis, driven by the interaction of p38 MAP kinase and LaminB1, which causes nuclear disintegration in 35% of Alzheimer's frontal cortex neurons.

New Form of Brain Cell Death May Explain How Dementia Destroys Neurons

Inside a dying brain cell, the first thing to go is the nucleus. Not the whole cell at once, not some tidy programmed shutdown, but the nucleus itself: the membrane around it buckles, the smooth sphere puckers and shrivels like fruit left too long in a bowl, and then it falls apart. Researchers at King’s College London have a name for this. They call it karyoptosis, and they think it accounts for a great deal of the neuronal loss that has long b…