New Drug Reverses Alzheimer's Memory Loss in Mice via Epigenetic Approach

Experimental Alzheimer's drug reverses memory loss in mice by reprogramming gene activity

A team from the University of Barcelona has designed and validated in animal models an innovative compound with a pioneering mechanism of action for the treatment of Alzheimer's disease. Unlike current drugs, which mainly remove beta-amyloid plaques that accumulate in the brain, this new experimental drug reprograms the neuronal epigenome by correcting alterations in gene expression that contribute to the progression of the disease.

First-in-class SAM-competitive G9a inhibitor FLAV-27 as a disease-modifying therapy for Alzheimer disease

Alzheimer's disease (AD) is characterized by a progressive cognitive decline involving a multifactorial pathophysiology, including epigenetic dysregulation. Here, we report the discovery and preclinical validation of FLAV-27, a first-in-class, S-adenosyl-l-methionine (SAM)-competitive, brain-penetra …

New drug may help treat Alzheimer’s disease more effectively

Scientists are working hard to find better ways to treat Alzheimer’s disease, one of the most common causes of memory loss and dementia around the world. A new study from researchers at the University of Barcelona has reported an exciting discovery. The team has designed a new experimental drug that works very differently from current […] The post New drug may help treat Alzheimer’s disease more effectively appeared first on Knowridge Science Re…

Researchers design a pioneering drug capable of reversing cognitive decline in Alzheimer’s disease in animal models

13.03.2026 - The new experimental compound works through an epigenetic mechanism that acts not only on the symptoms of the disease, but directly on the molecular mechanisms that contribute to its progression. Health A team from the University of Barcelona has designed and validated in animal models an innovative compound with a pioneering mechanism of action for the treatment of Alzheimer's diseas

Researchers design a pioneering drug capable of reversing cognitive decline in Alzheimer’s disease in animal models - Institute of Neurosciences of the Universitat de Barcelona

A team from the Institute of Neurosciences of the University of Barcelona (UBneuro) has designed and validated in animal models an innovative compound with a pioneering mechanism of action for... Read More from Researchers design a pioneering drug capable of reversing cognitive decline in Alzheimer’s disease in animal models