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Alzheimer's risk may be 35% lower with common menopause treatment, study finds

Researchers found estrogen-only therapy was linked to 35% lower odds of Alzheimer’s pathology and lower dementia risk, but said the study shows association only.

  • On Wednesday, a Stanford-led study published in the journal Neurology found that women using estrogen-only hormone therapy showed associations with lower Alzheimer's-related brain pathology and reduced dementia risk.
  • Researchers analyzed health records of 21,462 women from two large Alzheimer's databases, finding that users of estrogen-only therapy had 35% lower odds of Alzheimer's pathology at autopsy compared to non-users.
  • Study participants using the therapy also showed a 39% lower likelihood of a dementia diagnosis and lower amyloid levels in blood and spinal fluid, indicating reduced Alzheimer's-related brain changes.
  • Lead author Jennifer Bruno, an instructor at Stanford Medicine, emphasized that these observational findings do not change clinical recommendations and do not establish a cause-and-effect relationship.
  • Findings are most relevant to women who have had a hysterectomy, as estrogen-only therapy is appropriate only for that population; researchers call for future randomized trials to confirm protective effects.
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Women are significantly more affected by Alzheimer's than men. One reason may be the decline in sex hormones in menopause. A certain hormone therapy could protect, a recent study shows.

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Daily Post-Athenian broke the news on Wednesday, August 12, 2026.
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