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Mycobacterium Tuberculosis Does Not Inhibit NLRP1 and Pyrin Inflammasomes in Human Macrophages
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Mycobacterium Tuberculosis Does Not Inhibit NLRP1 and Pyrin Inflammasomes in Human Macrophages
Researchers investigated whether Mycobacterium tuberculosis or the nontuberculous mycobacteria Mycobacterium kansasii and Mycobacterium smegmatis can inhibit the NLRP1 or pyrin inflammasomes. They showed that none of the mycobacteria consistently inhibit the NLRP1 inflammasome after it is activated by priming with lipopolysaccharide and treatment with 1G244 in human macrophages. [Microbiology Spectrum] Full Article
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