US EditionMost people who stop weight-loss jabs regain all the weight within two years
Oxford researchers found patients regain all lost weight about 1.7 years after stopping GLP-1 drugs, with faster regain from newer therapies and fading cardiometabolic benefits.
- Recently, Oxford researchers in a BMJ review found most people returned to their original weight within about 1.7 years after stopping GLP-1 receptor agonists, pooling 37 trials with more than 9,000 participants.
- Scientists say GLP-1 drugs suppress appetite and increase fullness only while active, and when medication stops, appetite signals typically return, driving weight regain through biological adaptations.
- Newer-Generation GLP-1 therapies showed extrapolated weight regain of 0.3 kg monthly, 0.22 kg faster than behavioural programmes, with cardiometabolic markers projected to return to baseline in around 1.4 years.
- Clinicians advise tapering or maintenance dosing rather than abrupt cessation, with Dr Elise Dallas urging, `Plan ahead and don’t stop suddenly. You’ve got to taper, whether that be in time or dose`, while real-world observations estimate 50% of people with obesity discontinue within 12 months.
- Researchers recommend long-term planning, urging use of GLP-1 drugs with health coaches and psychological support, as obesity’s chronic nature may require prolonged treatment.
12 Articles
12 Articles
People who stop taking GLP-1 weight-loss medications like Ozempic and Mounjaro see their weight gain faster than those who lost weight through a modified diet or exercise. After two years, former users return to their previous weight, according to an analysis by Oxford University. Experts also emphasize the importance of lifestyle changes with proper nutrition, exercise, and strength training.
Alert over rebound effect as Ozempic weight loss reverses after treatment
Medical researchers are warning that patients who stop taking weight-loss drugs such as Ozempic frequently experience a rebound effect, with much of the weight lost during treatment returning within months. The findings, based on large-scale clinical trial data, are prompting renewed scrutiny of how glucagon-like peptide-1 (GLP-1) receptor agonists are prescribed and whether they should be… Source
Quitting weight-loss jabs like Ozempic and Mounjaro leads to rapid weight regain in 1.5 years, says new BMJ study
Like diabetes or BP medicines, these drugs work only as long as you take them, says endocrinologist Dr Ambrish Mithal. Dose reduction and long-term weight maintenance are key
Discontinuing weight loss drugs tied to weight regain
Stopping weight loss medication led to weight regain and reversed improvements in cardiometabolic markers in under 2 years, according to a new systematic review and meta-analysis.The data also suggest people gain weight faster after stopping medications vs. behavioral weight loss programs “regardless of how much weight was lost during treatment,” the researchers noted.
Miracle drugs against obesity have transformed millions of lives in just a few years. Ozempic, Wegovy, Mounjaro: these names have become synonymous with hope for those who fight against their weight. But a new British study has just documented what many already suspected: stopping these treatments is like releasing a compressed spring. [...]
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