NFL DFS, 49ers-Panthers: Top Daily Fantasy Picks for 'Monday Night Football'
ESPN gives the 49ers a 72.4% win probability and BetMGM Sportsbook lists them as 7-point favorites against the Panthers in Week 12 Monday Night Football.
- On November 24, 2025, the Carolina Panthers visit the San Francisco 49ers at Levi's Stadium, kickoff 8:15 p.m. ET; BetMGM Sportsbook lists the 49ers as a 7-point favorite with a moneyline of-350.
- Entering Week 12, San Francisco 49ers are 7-4 while Carolina Panthers sit 6-5, with the game's outcome factoring into the NFC playoff race and wild-card picture.
- ESPN's model gives San Francisco a 72.4% win probability, while Bookies.com recommends betting Carolina with the points, and The Arizona Republic predicts a 24 win for the 49ers.
- Fans can access live coverage via the ESPN app and Fubo, with gambling-risk notices reminding bettors they must be 21 or older and aware of financial risks.
- Christian McCaffrey faces his former team tonight, and Rico Dowdle has over 800 rushing yards through 11 games, while George Kittle is back from IR with four touchdowns in four games.
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49ers vs. Panthers live score, updates, highlights from NFL 'Monday Night Football' game
The Sporting News is tracking live scoring updates and highlights for 49ers vs. Panthers on "Monday Night Football." Follow for complete results from the NFL Week 12 prime-time game.
Week 12 MNF: Panthers-49ers Preview, Props, Prediction
Week 12 of the regular season closes with an intriguing matchup between a surprising team seeking a statement road win against a franchise trying to prove it still belongs among the NFL's top tier of contenders.Carolina (6-5) has won five of its past seven games, and a win on Monday night would vault the Panthers into sole possession of first place in the NFC South. The rare primetime game for Carolina comes at San Francisco, with the 49ers (7-4…
Week 12 MNF: Panthers-49ers Preview, Props, Prediction
Week 12 of the regular season closes with an intriguing matchup between a surprising team seeking a statement road win against a franchise trying to prove it still belongs among the NFL's top tier of contenders.
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