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Design and Evaluation of Biodegradable Self-Immolative Lipids for RNA Delivery
A new family of ionizable cationic lipids called “Self-Immolative Lipids” is reported. This innovative lipid architecture was designed to overcome a critical challenge in non-viral gene therapy: the need for a delivery vector that is both efficacious and stable during biodistribution while remaining biodegradable upon reaching the target cell. [Advanced Healthcare Materials] Abstract
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