US EditionMolecular and cellular mechanisms of cardiac fibrosis in Friedreich ataxia
Summary by Muscular Dystrophy Association
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Molecular and cellular mechanisms of cardiac fibrosis in Friedreich ataxia
"Friedreich ataxia (FA) is a genetic disease that frequently results in serious cardiac complications, primarily due to myocardial fibrosis, a form of heart muscle damage due to inflammation and scarring. In FA, the deficiency of a key mitochondrial protein called frataxin leads to swelling and eventual death of cardiomyocytes, which are heart muscle cells. This cell loss triggers inflammation and activates fibrotic pathways, resulting in the bu…
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