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Miami vs. Wake Forest odds, prediction: Week 3 college football picks for Friday
On Friday, September 18, 2026, fifth-ranked Miami Hurricanes travel to Winston-Salem to face Wake Forest Demon Deacons at 7:30 p.m. ET at Allegacy Federal Credit Union Stadium in an ACC matchup.
Both teams enter undefeated, with Miami quarterback Darian Mensah leading the nation's top offense alongside receiver Malachi Toney. Wake Forest counters with quarterback Gio Lopez, who earned ACC Quarterback of the Week honors last weekend.
The SportsLine projection model simulates every FBS game 10,000 times, with the Under on 55.5 points hitting in 66% of simulations. Miami is favored by 20.5 points.
Defensively, Miami will miss cornerback O.J. Frederique, Boree Antoine, and Xavier Lucas. Head coach Mario Cristobal emphasized his team must stay focused against Wake Forest's experienced, physical squad.
Looking ahead, the Hurricanes host Central Michigan on September 26. Friday's matchup remains critical for Miami's College Football Playoff aspirations and national title contention.