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Meta-Analysis Alleges Most Statin Side Effects Unfounded

A meta-analysis of over 154,000 participants found no strong evidence linking 62 of 66 potential statin side effects to the drugs, supporting their cardiovascular benefits.

  • On Thursday, the Cholesterol Treatment Trialists' Collaboration published a meta-analysis in The Lancet finding no significant excess risk for most statin leaflet-listed side effects, Associate Professor Christina Reith said.
  • Misinformation drove tens of thousands of Australians to stop statins, risking preventable heart attacks, as Associate Professor Christina Reith and Bryan Williams discussed safety concerns.
  • The analysis found data from 19 randomised double‑blind trials with over 154,000 participants and 38 million symptom reports, showing only four of 66 side-effects linked to statins, including small liver test abnormalities .
  • Authors have urged revising patient leaflets and have discussed changes with national regulators including the Therapeutic Goods Administration, advising patients and doctors to discuss any concerns.
  • From a public‑health perspective, more than 2 million Australians prescribed statins and 86 million Americans with high cholesterol could benefit as statins reduce heart attacks and strokes, which cause around 20 million deaths worldwide.
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midwesterndoctor.com broke the news in on Sunday, June 30, 2024.
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