Mayo Clinic's Gene Therapy Breakthrough Targets Most-Common Kidney Disease

Mayo Clinic's gene therapy breakthrough targets most-common kidney disease

The disease leads to the progressive growth of fluid-filled cysts in the kidneys, often resulting in kidney failure and other complications.

Base Editing Reverses Most Common Inherited Kidney Disease in Mice

Researchers at Mayo Clinic have developed a base editing therapy for autosomal dominant polycystic kidney disease (ADPKD), a genetic condition affecting one in 1,000 people. Their findings, published recently in Nature Communications, set a new precedent for treating genetic conditions affecting the kidneys, which have historically proven difficult to target with gene editing technologies.  “This is the first time we’ve been able to show that ba…

Mayo Clinic Uses Gene Editing to Reverse Inherited Kidney Disease in Preclinical Study

Mayo Clinic researchers have developed a promising gene-editing therapy that directly corrects a genetic mutation responsible for autosomal dominant polycystic kidney disease (ADPKD), the most common inherited kidney disorder.