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Exposure to Air Pollution in Womb Increases Risk of Asthma

  • Researchers presented a 2025 mouse study in San Francisco showing that prenatal air pollution exposure increases adult offspring asthma risk.
  • The study builds on prior research linking maternal pollution exposure to childhood asthma and explores epigenetic mechanisms affecting lung and immune genes.
  • Pregnant mice exposed to pollution produced adult offspring with stronger allergen-triggered airway constriction and altered DNA methylation in thousands of lung genes.
  • Dr. Razia Zakarya noted an epigenetic "memory effect" persisting into adulthood, with tested pollution levels meeting WHO air quality guidelines.
  • The findings highlight the need to shield expectant mothers from exposure to air pollutants and underscore the importance of further investigation into the molecular mechanisms involved, as well as potential methods to reverse epigenetic modifications.
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Exposure to air pollution in womb increases risk of asthma

Scientists also found that the children of mothers exposed to pollutants during pregnancy had lasting changes affecting their lungs.

·Cherokee County, United States
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Medical Xpress broke the news in on Tuesday, May 20, 2025.
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