Liver’s internal clock coordinates daily metabolic communication, study finds

Liver’s internal clock coordinates daily metabolic communication, study finds

What if one of the keys to a healthier metabolism is understanding how and when the liver communicates with the rest of the body?

Study: How The Liver Uses Its Daily Clock To Send Fat-Burning Signals

Researchers at UT Health San Antonio are shedding new light on a little-understood biological process that could eventually influence how scientists approach metabolic diseases: the liver’s ability to release different proteins at different times of day. The findings, highlighted Wednesday by UT Health San Antonio, show that the liver’s internal circadian clock helps determine when certain proteins are released and how those proteins interact wi…

The Circadian Clock Controls Hepatic Stellate Cell Activation via a BMAL1/CK1ε/REV-ERBα/Transgelin Signaling Pathway

Investigators showed that although the liver clock is generally maintained during human disease progression from a fatty liver to fibrosis, changes in circadian gene amplitude occur in people with obesity. [Proceedings of the National Academy of Sciences of the United States of America] Full Article