US EditionLithium shifts circadian rhythms early in bipolar disorder and may offer clues to treatment response
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Lithium shifts circadian rhythms early in bipolar disorder and may offer clues to treatment response
A randomized controlled trial shows that lithium treatment in bipolar disorder patients reduces daytime activity, advances its onset time, and increases volatility in circadian rest-activity patterns. These changes appear early and independently of mood, offering promise as early biomarkers of treatment response.
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