New 3D Lipid Atlas Maps the Chemistry of Mouse Brains
The map identifies 539 chemical territories and reveals unexpected white-matter diversity, giving researchers a new reference for studying brain development and disease.
- On Wednesday, Dr. Panos Roussos of the Icahn School of Medicine at Mount Sinai led researchers in publishing a massive atlas in Nature detailing gene activity in over 6.3 million brain cells.
- The PsychAD consortium, an NIH-funded partnership, developed this resource to connect genetic variations to brain disorders including Alzheimer's, Parkinson's, and schizophrenia, which have historically lacked detailed cellular-level understanding.
- Analyzing tissue from nearly 1,500 donors, Roussos and colleagues identified age 24 as a biological transition point where most prefrontal cortex cell types stabilize, providing a reference for distinguishing typical aging from disease-associated changes.
- "A useful treatment needs to influence the right biological process in the right cells," Roussos said, noting the map helps researchers narrow treatment targets and explain biological variation among patients with the same diagnosis.
- Separately, a team at EPFL led by Professor Giovanni D'Angelo released a Lipid Brain Atlas, mapping 539 distinct "lipizones" in mice to reveal how fatty molecules function as molecular postal codes across the brain.
21 Articles
21 Articles
Scientists Map Prefrontal Cortex Gene Activity, Revealing Clues to Alzheimer's, Parkinson's and Schizophrenia
WASHINGTON: Scientists have created a detailed map of gene activity within a crucial part of the brain called the prefrontal cortex, gaining insight into normal development and major brain disorders such as Alzheimer's disease, Parkinson's disease and schizophrenia.In nine separate studies, the researchers examined changes in individual types of brain cells that occur over time and made progress toward deciphering molecular processes that under…
Includes 6.3 million cells, will also help clarify many diseases (ANSA)
First map of mouse brain lipids reveals over 500 biochemical zones
The brain is often described in terms of cells and wiring. However, much of it is made of lipids that form the membranes of neurons, wrap nerve fibers with myelin and help brain cells send and receive signals.
New 3D lipid atlas maps the chemistry of mouse brains
The brain is often described in terms of cells and wiring. However, much of it is made of lipids that form the membranes of neurons, wrap nerve fibers with myelin, and help brain cells send and receive signals.
Laboratory assistant holds a hemisphere of a healthy human brain at Belle Idee University Hospital in Chene-Bourg, near Geneva. March 14, 2011. REUTERS/Denis Balibouse Scientists created a detailed map of gene activity in a crucial part of the brain called prefrontal cortex, obtaining new insights into normal development and major brain diseases such as Alzheimer's, Parkinson's and schizophrenia. In nine separate studies, researchers examined ch…
Scientists map gene activity in brain’s prefrontal cortex
By Will Dunham WASHINGTON, Sept 23 (Reuters) - Scientists have created a detailed map of gene activity within a crucial part of the brain called the prefrontal cortex, gaining insight into normal development and major brain disorders such as Alzheimer'...
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