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Angiography-Guided PCI Assessment Confers Similar Outcomes to FFR for Intermediate Lesions
The ALL-RISE Trial found CathWorks FFRangio matched invasive pressure wire outcomes with a 6.9% major adverse cardiac event rate, while reducing procedure time and resource use.
- On Monday, March 30, 2026, researchers presented ALL-RISE trial results at the American College of Cardiology Scientific Session in New Orleans, showing CathWorks FFRangio achieved non-inferiority to invasive pressure wire guidance for cardiac outcomes.
- The randomized trial enrolled 1,930 patients across 59 global sites to evaluate whether AI-assisted 3D modeling could reliably determine lesion severity compared to traditional, more invasive pressure wire-based diagnostic procedures.
- At one year, the primary endpoint event rate was 6.9% for the FFRangio group and 7.1% for the pressure wire group, with no significant differences in safety events like bleeding or acute kidney injury.
- Using the FFRangio model required less total contrast volume and resulted in shorter physiology assessment, fluoroscopy, and overall procedure times, offering a simplified workflow compared to the current standard.
- Global Principal Investigator Dr. Ajay Kirtane stated the results demonstrate the technology's potential to become a new standard, while experts described these computational tools as a glimpse into future cath lab workflows.
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Angiography-guided PCI assessment confers similar outcomes to FFR for intermediate lesions
NEW ORLEANS — In patients with intermediate coronary lesions, an angiography-guided percutaneous coronary intervention strategy was noninferior to a pressure wire-guided PCI strategy for CV outcomes at 1 year, new data show. The ALL-RISE trial, presented at the American College of Cardiology Scientific Session and simultaneously published in The New England Journal of Medicine, showed that
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