US EditionJCI Endothelial dysfunction in patients with type 2 diabetes: the truth is in the blood
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JCI Endothelial dysfunction in patients with type 2 diabetes: the truth is in the blood
Endothelial dysfunction remains a cornerstone of diabetic vascular complications. RBCs emerge as pivotal players in endothelial dysfunction, yet the underlying mechanisms remain elusive. In this issue of the JCI, Collado et al. show that the detrimental action of RBCs on the endothelium is mediated by extracellular vesicles (EVs). EVs derived from RBCs (RBC-EVs) of patients with diabetes were taken up by the endothelium and were able to impair e…
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