WSTF Nuclear Autophagy Regulates Chronic but Not Acute Inflammation

WSTF nuclear autophagy regulates chronic but not acute inflammation

Acute inflammation is an essential response that our bodies use to combat infections1. However, in the absence of infections, chronic inflammation can have a pivotal role in the onset and progression of chronic diseases, such as arthritis, cancer, autoimmune disorders, metabolic-dysfunction-associated steatohepatitis (MASH), and most ageing-associated pathologies2,3. The underlying mechanisms that distinguish chronic inflammation from its acute …

Scientists Discover Novel Protein Target to Regulate Chronic Inflammation

Chronic inflammation represents one of the most perplexing and enduring challenges in modern medicine, persisting for months or even years as the immune system remains locked in a prolonged state of defense and repair. Unlike acute inflammation, which acts swiftly and resolves as the body heals from injury or infection, chronic inflammation can silently erode […]

JCI Autophagy is an upstream mediator of chromatin dynamics in normal and autoimmune germinal center B cells

Germinal center (GC) B cells are pivotal in establishing a robust humoral immune response and long-term serological immunity while maintaining antibody self-tolerance. GC B cells rely on autophagy for antigen presentation and homeostatic maintenance. However, these functions, primarily associated with the light zone, cannot explain the spatiotemporal autophagy upregulation in the dark zone of GCs. Here, combining imaging, molecular, and genomic …