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What to Know About a Rapidly Rising Form of Breast Cancer that’s Hard to Detect

Invasive lobular carcinoma cases in the U.S. are rising 2.8% yearly, nearly three times faster than other breast cancers, posing detection and treatment challenges, American Cancer Society reports.

  • The American Cancer Society found invasive lobular carcinoma rates rose nearly 3% annually, outpacing other breast cancers that rose just under 1%, with 33,600 cases projected in 2025.
  • Amid shifting population health trends, researchers suggest that higher obesity, increasing alcohol use, and changes in reproductive timing may be linked to the rising invasive lobular carcinoma rates, which ACS reports are increasing at about 3% per year.
  • Because ILC doesn't form a defined mass, its linear growth and thin strands make mammograms less effective, while ultrasound and breast MRI show uncertain benefits for screening clinicians.
  • Clinical researchers warn that grouping invasive lobular carcinoma with invasive ductal carcinoma in clinical trials masks ILC's traits, delaying diagnosis and complicating treatment.
  • With more lobular-specific research underway, study authors and advocates call for genetic studies and recommend limiting alcohol, staying active, and monitoring non-lump symptoms for early diagnosis.
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EverydayHealth.com broke the news in on Tuesday, October 21, 2025.
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