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What Does It Mean for Biden's Prostate Cancer to Be 'Aggressive'? A Urologic Surgeon Explains

  • On Sunday, it was disclosed that Joe Biden, the former U.S. President, has been found to have an advanced prostate cancer with a Gleason score of 9, which has metastasized to his bones.
  • This diagnosis followed urinary symptoms and classification of Gleason 9 cancer in grade group 5, which indicates cells very abnormal with strong growth potential.
  • Prostate cancer stages range from localized , locally advanced , to metastatic , where Biden's cancer is Stage 4 due to bone spread, considered advanced and aggressive.
  • Nearly seven out of ten prostate cancer cases are diagnosed while the disease is still confined to the prostate, with early-stage patients experiencing nearly a 100% chance of surviving five years. In contrast, those with metastatic Stage 4 prostate cancer face a substantially lower five-year survival rate of approximately 38%.
  • Treatment for metastatic prostate cancer usually focuses on stopping further spread, and Biden’s family is reviewing options amid ongoing assessments and genomic testing recommendations.
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The Hayride broke the news in on Wednesday, May 21, 2025.
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