Rapid and Sustained Antidepressant Effects of Vaporized N,N-Dimethyltryptamine: a Phase 2a Clinical Trial in Treatment-Resistant Depression

Rapid and sustained antidepressant effects of vaporized N,N-dimethyltryptamine: a phase 2a clinical trial in treatment-resistant depression

Depression affects over 185 million people worldwide, with approximately one-third classified as treatment-resistant depression (TRD). Current treatments, such as oral antidepressants, often take around 3 weeks to become effective, with no immediate anti-suicidal benefits. The field urgently needs innovative therapies that provide rapid relief. Psychedelics like psilocybin and ayahuasca have shown promising antidepressant effects; however, their…

Inhaled DMT produces rapid and lasting antidepressant effects in treatment-resistant depression

A new study published in Neuropsychopharmacology has found that inhaled N,N-dimethyltryptamine (DMT), a fast-acting psychedelic compound, produced rapid and sustained antidepressant effects in people with treatment-resistant depression. Participants reported major reductions in depression and suicidal thoughts within a day of dosing, with benefits lasting up to three months. The therapy was safe, well-tolerated, and may offer a more accessible a…