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Indianapolis Colts Injury Report Week 6: Will Arizona Cardinals Quarterback Kyler Murray Play vs. Colts?

Kyler Murray remains day-to-day with a foot injury sustained in Week 5, with his participation uncertain for Week 6 against the Colts, as the Cardinals seek to end a three-game losing streak.

  • On Wednesday, Oct. 8, Arizona Cardinals quarterback Kyler Murray did not practice, and his availability for the Oct. 12 game at Indianapolis remains uncertain.
  • In the third quarter of Week 5, Kyler Murray sustained a foot injury after a shotgun snap struck his face, causing a fumble; he left for a locker room evaluation, missed two plays, then returned.
  • This season, Kyler Murray is completing 68.3% of his passes for 962 yards with six touchdowns and three interceptions, and he has run 29 times for 173 yards and a touchdown.
  • If Murray cannot go on Sunday, veteran backup Jacoby Brissett would start as Arizona Cardinals face a tough 4-1 Indianapolis Colts defense at Lucas Oil Stadium.
  • Given Murray's injury history, he hasn't missed a game since returning from a torn ACL in 2023, and Jonathan Gannon, Arizona Cardinals head coach, praised his work, saying `He loves to practice, he loves to prepare, he loves to play`.
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Sportsnet broke the news in Canada on Wednesday, October 8, 2025.
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