Improved method for producing designer proteins prevents misfolding

Machine learning for functional protein design

Recent breakthroughs in AI coupled with the rapid accumulation of protein sequence and structure data have radically transformed computational protein design. New methods promise to escape the constraints of natural and laboratory evolution, accelerating the generation of proteins for applications in biotechnology and medicine. To make sense of the exploding diversity of machine learning approaches, we introduce a unifying framework that classif…

Improved method for producing designer proteins prevents misfolding

Proteins are the building blocks of life. They consist of folded peptide chains, which in turn are made up of a series of amino acids. From stabilizing cell structure to catalyzing chemical reactions, proteins have many functions. Their diversity is further increased by modifications that take place after the peptide chains have been synthesized.

Effect of pH and temperature on fibrous structure formation of plant proteins during high-moisture extrusion processing

This study investigated the effect of pH on fibrous structure formation (protein alignment) during high-moisture extrusion processing of gluten, rice …

Proteins are building blocks of life. They consist of folded peptide chains, which in turn are composed of interlinked amino acids. From the stabilization of the cell structure to the catalysis of chemical reactions, proteins have many functions. Their diversity is caused by changes in the structure of the cells.

Research team improves method for producing designer proteins: Long-standing problem solved

10.04.2025 - Long-standing problem solved: Researchers discover that misfolding prevents efficient utilisation of so-called split inteins as 'protein glue'. Proteins are the building blocks of life. They consist of folded peptide chains, which in turn are made up of a series of amino acids.