US EditionCommon Medications Impact Gut Microbiome and Promote Pathogen Growth
TÜBINGEN, GERMANY, JUL 16 – Study reveals one-third of common non-antibiotic drugs disrupt gut bacteria and promote Salmonella growth, urging drug safety evaluations to include microbiome impact, researchers say.
- A new study published in Nature shows that many medications, including digoxin, are associated with microbiome alterations at the University of Tübingen, CMFI, and IMIT, directed by Professor Lisa Maier.
- Addressing a healthcare paradox, the study analyzed 53 common non-antibiotic medications, including allergy remedies, antidepressants, and hormone drugs, over a fifteen-year cohort of over one million individuals.
- In mouse experiments, digoxin, a cardiac glycoside, associated with elevated Salmonella rates, altered microbiome architecture, and fecal transplants confirmed increased infection susceptibility.
- Consequently, and researchers urge clinicians and researchers to include microbial effects in drug safety evaluations.
- Such insights emphasize the need to incorporate microbiome effects into future therapeutic strategies, and findings suggest developing interventions to mitigate microbiome–drug–pathogen interactions in vulnerable populations.
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Medical experts recommend the 5R approach — remove toxins, replace enzymes, reinoculate good bacteria, repair gut lining and rebalance lifestyle — to improve gut health and boost immunity.
Unexpected side effect: How common medications clear the way for pathogens
The human intestine is home to a dense network of microorganisms, known collectively as the gut microbiome, which actively helps to shape our health. The microorganisms help with digestion, train the immune system and protect us against dangerous intruders. However, this protection can be disrupted, and not just by antibiotics, which—when used for treatment—are intended to prevent the growth of pathogenic bacteria.
Identification of medication–microbiome interactions that affect gut infection
Most people in the USA manage their health by taking at least one prescription drug, and drugs classified as non-antibiotics can adversely affect the gut microbiome and disrupt intestinal homeostasis1,2. Here we identify medications that are associated with an increased risk of gastrointestinal infections across a population cohort of more than one million individuals monitored over 15 years. Notably, the cardiac glycoside digoxin and other drug…
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