mRNA-based COVID-19 vaccines train the 'long-term memory' of the immune system

Rewriting the Brain’s Rulebook: Scientists Uncover Memory’s Hidden Architecture

New structural markers of memory storage uncovered by Scripps Research may pave the way for new treatments for memory loss. Using advanced genetic tools, 3D electron microscopy, and artificial intelligence, scientists at Scripps Research and their collaborators have identified key hallmarks of long-term memory, known as an engram. Published in Science on March 20, 2025, [...]

mRNA-based COVID-19 vaccines train the 'long-term memory' of the immune system

Researchers have discovered that mRNA-based COVID-19 vaccines have a persistent effect on the innate immune system. These mechanisms may help the human body to better protect itself against potential future infections.

The novel mRNA vaccines against COVID-19 not only elicit classic immune responses of the adaptive immune system, such as antibody production, but also lead to long-lasting epigenetic changes in defense cells of the innate immune system. This is the result...

mRNA-based COVID-19 vaccines train the 'long-term memory' of the immune system, study reveals - Science Tech Updates

Researchers at the University of Cologne and University Hospital Cologne have determined that the novel mRNA-based COVID-19 vaccines not only induce acquired immune responses such as antibody production, but also cause persistent epigenetic changes in innate immune cells. The study, “Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages,” led by Professor Dr. Jan […] The post mRNA-based COVID-19 vaccines tra…

AI learns to 'speak' genetic 'dialect' for future SARS-CoV-2 mutation prediction

It's been five years since COVID-19 was declared a global pandemic. As SARS-CoV-2 shifts to endemic status, questions about its future evolution remain. New variants of the virus will likely emerge, driven by positive selection for traits such as increased transmissibility, longer infection duration and the ability to evade immune defenses. These changes could allow the virus to spread among previously immunized populations, potentially triggeri…

Researchers at the University of Cologne show that COVID-19 vaccines based on mRNA shape the congenital immune system in the long term. These mechanisms can cause the human body to react faster and more widely to future infections.