Moores Cancer Center Seeks Critical Grant Renewal Amid Federal Uncertainty

Moores Cancer Center seeks critical grant renewal amid federal uncertainty

Two years after facing criticism that its clinical trials office was in “profound disarray,” UC San Diego Moores Cancer Center is pursuing renewal of a key federal grant with confidence, its new leader pointing to significant gains in local oncology research that she says show the university’s comprehensive cancer program is thriving. Dr. Diane Simeone, a well-known pancreatic cancer researcher and Moores’ executive director, worked last week to…

"Pancreatic cancer doubles every six years in France," said Green MP Sandrine Rousseau, on Monday 26 May on the LCP parliamentary channel. "It is true that pancreatic cancer is becoming, in the 2030s, the second leading cause of cancer mortality after lung cancer, in Europe and the United States, as Le Monde says, it is not pesticides that are the main cause of it, because the main causes are smoking, excessive alcohol consumption and obesity, a…

HMGA2 and Protein Leucine Methylation Drive Pancreatic Cancer Lineage Plasticity

Scientists identified elevated levels of LIN28B and its downstream target, high-mobility group protein AT-hook 2 (HMGA2), in basal PDAC. Notably, LIN28B significantly accelerates KRAS-driven PDAC progression in a mouse model. [Nature Communications] Full Article

HMGA2 and Leucine Methylation Fuel Pancreatic Cancer Plasticity

In a groundbreaking study poised to redefine our understanding of pancreatic cancer, researchers have unveiled a complex molecular mechanism involving HMGA2 and protein leucine methylation that orchestrates lineage plasticity within tumor cells. This breakthrough provides a compelling explanation for one of the most confounding aspects of pancreatic ductal adenocarcinoma (PDAC)—its remarkable ability to adapt and resist treatment through cellula…