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Study Links High THC Levels with Egg Quality and Fertility Issues
The study links high tetrahydrocannabinol levels to disrupted chromosome segregation and lower embryo quality, with 42% of THC-exposed eggs showing complex aneuploidy, researchers said.
- Researchers led by Cyntia Duval found that THC exposure alters human egg development and chromosome alignment, affecting fertility as reported on Sept. 9 in Nature Communications.
- The study integrated laboratory exposure of eggs to THC with clinical data obtained from a group of women undergoing fertility treatment whose ovarian fluid tested positive for the compound, helping to fill gaps in understanding the direct impact of cannabis on oocyte quality.
- Women with detectable THC had higher egg maturation rates but produced fewer embryos with correct chromosomes, linked to increased spindle abnormalities that disrupt embryo development.
- Duval explained that although there may be an increased number of mature oocytes, this could come at a cost if the chromosomes are not properly aligned, potentially affecting embryo health. Meanwhile, Dr. Jamie Lo emphasized the need for caution with cannabis use when trying to conceive.
- These findings highlight potential fertility risks amid rising cannabis use, especially with THC potency quadrupling since 1995, and support harm-reduction strategies though causality remains unproven and requires further study.
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High THC Levels May Affect Egg Quality and Fertility, New Study Finds
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·Calhoun, United States
Read Full ArticleCan cannabis use disrupt women’s fertility? New study finds strong evidence
Researchers found that THC, the psychoactive compound in cannabis, alters oocyte gene expression, spindle formation, and chromosome segregation, lowering embryo euploidy rates in IVF. This provides direct human evidence linking cannabis exposure to impaired female fertility outcomes.
·United States
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Total News Sources22
Leaning Left2Leaning Right3Center4Last UpdatedBias Distribution44% Center
Bias Distribution
- 44% of the sources are Center
44% Center
L 22%
C 44%
R 33%
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