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Study Links High THC Levels with Egg Quality and Fertility Issues

The study links high tetrahydrocannabinol levels to disrupted chromosome segregation and lower embryo quality, with 42% of THC-exposed eggs showing complex aneuploidy, researchers said.

  • Researchers led by Cyntia Duval found that THC exposure alters human egg development and chromosome alignment, affecting fertility as reported on Sept. 9 in Nature Communications.
  • The study integrated laboratory exposure of eggs to THC with clinical data obtained from a group of women undergoing fertility treatment whose ovarian fluid tested positive for the compound, helping to fill gaps in understanding the direct impact of cannabis on oocyte quality.
  • Women with detectable THC had higher egg maturation rates but produced fewer embryos with correct chromosomes, linked to increased spindle abnormalities that disrupt embryo development.
  • Duval explained that although there may be an increased number of mature oocytes, this could come at a cost if the chromosomes are not properly aligned, potentially affecting embryo health. Meanwhile, Dr. Jamie Lo emphasized the need for caution with cannabis use when trying to conceive.
  • These findings highlight potential fertility risks amid rising cannabis use, especially with THC potency quadrupling since 1995, and support harm-reduction strategies though causality remains unproven and requires further study.
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High THC Levels May Affect Egg Quality and Fertility, New Study Finds

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News Medical broke the news in United States on Thursday, September 11, 2025.
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