NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are not understood, and whether the metabolic deficit can be targeted for therapeutic intervention has not been determined. Here we report impaired mitophagy and depletion of NAD+, a fundamental ubi…

Healthspan and longevity: The rise of the ‘geroprotective supplements’

Our understanding of the aging process is leading to a range of intriguing bioactives to prolong healthspan, including resveratrol, nicotinamide riboside, urolithin A, spermidine and many others. This articles explores a selection of the key ingredients for longevity supplements.