US EditionHarnessing the highly adaptable barnase-barstar system for genetic biocontrol of Aedes aegypti
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Harnessing the highly adaptable barnase-barstar system for genetic biocontrol of Aedes aegypti
Harnessing the highly adaptable barnase-barstar system for genetic biocontrol of Aedes aegypti Toxin-antidote pairs can be used in gene drive systems, providing powerful means to modify mosquito populations. Here we use the toxin-antidote pair, barnase and barstar, originally identified in Bacillus amyloliquefaciens, due to their high binding affinity, small size and lack of need for cofactors. In Ae. aegypti cell culture, we find that barnase c…
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