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Pesticides Endanger People's Good Gut Microbes
A screening of 1,076 chemicals found 168 harmful to gut bacteria, some inducing antibiotic resistance, highlighting overlooked risks in current safety assessments.
- University of Cambridge researchers screened 1,076 chemicals, including 829 pesticides, against 22 gut bacteria species and identified 168 chemicals toxic to gut bacteria, publishing results in Nature Microbiology.
- Because many industrial chemicals lack microbiome data, the University of Cambridge team tested them, noting standard chemical safety assessments omit gut microbiome effects despite likely food, water and environmental exposure.
- Specific chemicals like Tetrabromobisphenol A and Closantel inhibited 19 bacterial strains while Hexachlorophene stifled 20, with pollutant resistance overlapping antibiotic resistance, including Ciprofloxacin.
- Microbiome disruption is linked to a range of health issues, the authors note, urging researchers to collect more exposure data and advise the public to wash fruit and vegetables and avoid garden pesticides.
- The study highlights regulatory gaps in testing for microbiome impacts as study authors warn regulators do not adequately assess chemicals for gut health, and they published a prototype machine-learning model to predict harmful chemicals.
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Industrial and agricultural chemicals such as pesticides are often considered to have restricted biological activity. Yet, there are concerns regarding their broader toxicity range and impact on human gut microbiota. Here we report a systematic in vitro screening to assess the impact of 1,076 pollutants, spanning diverse chemistries and indicated applications, on 22 prevalent gut bacteria. Our investigation uncovered 588 inhibitory interactions …
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Coverage Details
Total News Sources33
Leaning Left4Leaning Right3Center9Last UpdatedBias Distribution56% Center
Bias Distribution
- 56% of the sources are Center
56% Center
L 25%
C 56%
R 19%
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