US EditionChlamydia Pneumoniae and SARS-CoV-2 Infections May Play a Role in Alzheimer's Pathogenesis
PENNSYLVANIA, USA, JUL 13 – Researchers at Philadelphia College of Osteopathic Medicine found infections increase brain inflammation and may raise Alzheimer's risk, especially in those with a genetic susceptibility, study shows.
- A July 13, 2025 review by Philadelphia College of Osteopathic Medicine researchers suggests Chlamydia pneumoniae and SARS-CoV-2 infections may contribute to Alzheimer's disease pathogenesis by increasing brain inflammation.
- This review builds on scientific findings that both infections elevate cytokines like IL-6 and CCL2, causing ongoing inflammation that potentially accelerates harmful protein buildup linked to Alzheimer's.
- Supporting studies from Yale show SARS-CoV-2 spike protein induces amyloid beta aggregates in retinal tissue, highlighting NRP1 as a molecular target for preventing viral-triggered amyloid pathology and neurological effects such as brain fog.
- Popstar Peter Andre expressed empathy toward Fiona Phillips and her family, who share personal struggles coping with Alzheimer's after Fiona's 2022 diagnosis, while her husband Martin stepped down from ITV in February 2025 to care for her.
- These findings link infections to Alzheimer's mechanisms and suggest new prevention and treatment avenues, while personal accounts reflect the emotional impact on affected families and reinforce the need for further research.
14 Articles
14 Articles
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In the race to understand and treat dementia and Alzheimer’s disease, an important new discovery was just made by researchers at Johns Hopkins University. This revelation can change how we potentially catch and diagnose cognitive decline as Americans age. Specifically, two proteins in the brain have long been associated with the development of Alzheimer’s: A-beta (or amyloid-beta), a group of proteins that form a visible plaque outside of neuron…
Two common infections may cause Alzheimer's, scientists warn - are you at risk?
SCIENTISTS have spent decades trying to understand what causes dementia. Is it alcohol? Obesity? Or are some of us simply genetically predisposed? GettyTwo common infections may play a role in the development of Alzheimer’s[/caption] The evidence is mixed – though experts generally agree that there are several factors involved in the abnormal build-up of proteins called amyloid and tau, which are what cause symptoms. A new review by Philadelphia…
Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk
Chlamydia pneumoniae is a respiratory tract pathogen but can also infect the central nervous system (CNS). Recently, the link between C. pneumoniae CNS infection and late-onset dementia has become increasingly evident. In mice, CNS infection has been shown to occur weeks to months after intranasal inoculation. By isolating live C. pneumoniae from tissues and using immunohistochemistry, we show that C. pneumoniae can infect the olfactory and trig…
Alzheimer’s Iceberg: 200+ Hidden Proteins That May Be Quietly Destroying Memory
A groundbreaking study has revealed over 200 misfolded proteins in the brains of aging rats with cognitive impairment, far beyond the well-known amyloid and tau plaques. These newly identified proteins don’t form the typical clumps seen under microscopes, making them harder to detect but potentially just as dangerous. Scientists believe these stealthy molecules might be [...]
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