Glucosamine supplements may speed memory loss from Alzheimer’s, new research shows
Researchers found glucosamine use was linked to a 25% higher risk of dementia progression and a 25% increase in mortality among Alzheimer’s patients.
- Researchers reported in Nature Metabolism on Tuesday that a retrospective study of 65,000 patients found glucosamine use correlates with a 25% higher risk of progression from mild cognitive impairment to Alzheimer's disease.
- University of Florida neuroscientists discovered the Alzheimer's brain adds excessive sugar structures to proteins through N-glycosylation; glucosamine crosses the blood-brain barrier and fuels this overactive system.
- In genetically modified mice, the supplement significantly increased sugar attachment to proteins, causing deficits in 'social memory,' noted senior author Ramon Sun, Ph.D., of the University of Florida McKnight Brain Institute.
- Matt Gentry, Ph.D., chair of the University of Florida Department of Biochemistry and Molecular Biology, called the findings 'very provocative' but noted the study shows association rather than causation.
- With more than 40 million Americans using the supplement annually, researchers hope these results will prompt investigation into metabolic dysfunction as a targetable pathway for combating Alzheimer's disease.
52 Articles
52 Articles
Common supplement may accelerate memory loss from Alzheimer's disease
People with Alzheimer’s disease who took the common supplement glucosamine were 25% more likely to die within five years than those who didn’t. That’s the key finding of a new study that my colleagues and I published in the journal Nature Metabolism. Glucosamine is a sugar molecule that’s sold over the counter as a remedy for joint pain and arthritis. More than 40 million Americans take it each year. We found that glucosamine also affected peopl…
Joint pain supplement taken by millions may speed up Alzheimer's disease progression, scientists warn
A widely used joint health supplement may accelerate cognitive decline in vulnerable patients, according to research published today by University of Florida neuroscientists.The study, appearing in Nature Metabolism, found that individuals taking glucosamine faced a 25 per cent greater likelihood of progressing from mild cognitive impairment to Alzheimer's disease.Glucosamine remains one of the most popular over-the-counter remedies for joint pa…
Popular joint supplement glucosamine linked to faster Alzheimer’s progression
A major study suggests glucosamine, a popular supplement for joint pain, could be linked to faster progression from mild cognitive impairment to Alzheimer’s disease. Researchers found a 25% higher likelihood of developing dementia among glucosamine users and uncovered biological clues that may explain why.
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