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An ancient RNA-guided system could simplify delivery of gene editing therapies

Summary by ecotopical.com

A vast search of natural diversity has led scientists at MIT's McGovern Institute and the Broad Institute of MIT and Harvard to uncover ancient systems with the potential to expand the genome-editing toolbox. These systems, which the researchers call TIGR (Tandem Interspaced Guide RNA) systems, use RNA to guide them to specific sites on DNA.

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Scientific Inquirer

An ancient RNA-guided system could simplify delivery of gene editing therapies - Scientific Inquirer

A vast search of natural diversity has led scientists at MIT’s McGovern Institute and the Broad Institute of MIT and Harvard to uncover ancient systems with potential to expand the genome editing toolbox. These systems, which the researchers call TIGR (Tandem Interspaced Guide RNA) systems, use RNA to guide them to specific sites on DNA. TIGR systems can be reprogrammed to target any DNA sequence of interest, and they have distinct functional mo…

9 days ago

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Tech and Science Post

An ancient RNA-guided system could simplify delivery of gene editing therapies - Tech and Science Post

A vast search of natural diversity has led scientists at MIT’s McGovern Institute and the Broad Institute of MIT and Harvard to uncover ancient systems with the potential to expand the genome-editing toolbox. These systems, which the researchers call TIGR (Tandem Interspaced Guide RNA) systems, use RNA to guide them to specific sites on DNA. TIGR systems can be reprogrammed to target any DNA sequence of interest, and they have distinct functiona…

11 days ago

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Inside Precision Medicine

Zhang Lab Discovers Ancient RNA System That Could Simplify Gene Editing

Researchers at MIT’s McGovern Institute and the Broad Institute of MIT and Harvard have discovered an RNA-guided system, dubbed TIGR (Tandem Interspaced Guide RNA), that could provide a more versatile and compact tool for gene editing, which could even overcome some limitations of CRISPR-based gene editing systems. The investigators noted, in a report published in Science, that TIGR is very compact compared with other gene editing systems, inclu…

12 days ago

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Prader-Willi Syndrome News

Gene-editing tool successfully reactivates genes in PWS lab study

Researchers have successfully used the gene-editing tool CRISPR to reactivate certain maternally-inherited genes that can compensate for the loss of the corresponding paternally-inherited genes in Prader-Willi syndrome (PWS). Done using lab-grown human stem cells with a PWS-causing mutation, the work showed that the one-time approach resulted in a sustained effect in the cells, according to the researchers. “This work provides proof of concept f…

13 days ago

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Broad Institute

+2 Reposted by 2 other sources

An ancient RNA-guided system could simplify delivery of gene editing therapies

An ancient RNA-guided system could simplify delivery of gene editing therapies By Corie Lok February 27, 2025 Breadcrumb Home An ancient RNA-guided system could simplify delivery of gene editing therapies The programmable proteins are compact, modular, and can be directed to modify DNA in human cells. By Jennifer Michalowski, McGovern Institute February 27, 2025 Credit: Max Wilkinson The Tas protein uses an RNA guide to recognize a specific ta…

13 days ago

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