US Edition'I Wasn't Let Into Jobcentre because of My Autism Assistance Dog'
PRINCETON UNIVERSITY, JUL 10 – Researchers analyzed data from over 5,000 children with autism to define four distinct genetic subtypes, each linked to unique developmental timelines and behavioral traits, enabling personalized care.
- On July 9, Princeton University and Simons Foundation researchers defined four autism subtypes using SPARK cohort data, linking each to unique genetic profiles.
- Despite high heritability yet scarce clear causes, researchers built on over a decade of autism genomics research led by Olga Troyanskaya, supported by SF and NIH, to seek finer autism subtypes.
- Using a person-centered model, researchers identified distinct mutation patterns, with Broadly Affected children showing more de novo mutations and different developmental timelines.
- The researchers said, `It could tell families...` while `Understanding genetic causes...`, said Jennifer Foss-Feig.
- Beyond autism, the approach could extend to characterizing other complex, heterogeneous conditions, helping anticipate diagnosis and treatment paths and offering a framework for future research.
17 Articles
17 Articles
Autism affects 8,000 babies every year in France and affects 1 to 2% of births. Specialists are still deprived of this disease and some profiles are still unknown, such as pathological avoidance syndrome. - What is the pathological avoidance syndrome of demands, this unknown profile of autism? (Health and well-being).
Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs
Unraveling the phenotypic and genetic complexity of autism is extremely challenging yet critical for understanding the biology, inheritance, trajectory and clinical manifestations of the many forms of the condition. Using a generative mixture modeling approach, we leverage broad phenotypic data from a large cohort with matched genetics to identify robust, clinically relevant classes of autism and their patterns of core, associated and co-occurri…
The Independent
The Independent (US)Major autism breakthrough could revolutionise treatments and care
The ‘person-centred’ research found four distinct subtypes of autism that researchers believe could be vital in understanding the biology of the genetic condition
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