FDA Expands Guselkumab Approval to Crohn's Disease

Cellular mechanisms that may lead to onset of inflammatory bowel disease

New study shows that dysfunction of protective immune cells in GI tract may contribute to onset of inflammation in Crohn's disease.

FDA Expands Guselkumab Approval to Crohn's Disease

(MedPage Today) -- The FDA expanded the approval of guselkumab (Tremfya) to include treatment of moderately to severely active Crohn's disease, drugmaker Johnson & Johnson announced on Thursday. An interleukin (IL)-23 inhibitor that also binds...

Immune cell dysfunction in GI tract may lead to onset of inflammatory bowel disease

A research team led by Mount Sinai has uncovered mechanisms of abnormal immune cell function that may lead to Crohn's disease, according to findings published in Science Immunology. The researchers said their discovery provides a better understanding of disease development and could inform the development and design of new therapies to prevent inflammation before it starts in the chronic disorder.

Finding Clinical Trial Resources - The Morning Sun

(Family Features) If you have Crohn’s disease or ulcerative colitis, a clinical trial may be an option for you. Clinical trials are necessary for finding new ways of preventing, detecting or treating these diseases and others. To learn more about inflammatory bowel disease clinical research, visit crohnscolitisfoundation.org/clinical-trials-community and consider resources from the Crohn’s & Colitis Foundation that can provide information on typ…

Researchers find mechanisms that may lead to inflammatory bowel...

Last Updated on March 23, 2025 by Team THIP New York, March 23 (IANS) A team of scientists has discovered mechanisms of abnormal immune cell function that may lead to Crohn’s disease, an inflammatory bowel disease (IBD). Crohn’s disease causes chronic inflammation of the gastrointestinal (GI) tract, and symptoms can include abdominal pain, diarrhoea, weight […] The post Researchers find mechanisms that may lead to inflammatory bowel disease appe…