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Expanding the Druggable Proteome with Tech Advances
Drug discovery has long faced a stubborn reality: Most disease-relevant proteins lack the deep, hydrophobic pockets required for inhibition by conventional small-molecule drugs. Beginning in the early 2000s, researchers began framing this challenge in terms of druggability—whether a given protein can bind effectively to traditional therapeutics.1 Transcriptional regulators, scaffolding proteins, and intrinsically disordered domains were therefor…
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1 Articles
Expanding the Druggable Proteome with Tech Advances
Drug discovery has long faced a stubborn reality: Most disease-relevant proteins lack the deep, hydrophobic pockets required for inhibition by conventional small-molecule drugs. Beginning in the early 2000s, researchers began framing this challenge in terms of druggability—whether a given protein can bind effectively to traditional therapeutics.1 Transcriptional regulators, scaffolding proteins, and intrinsically disordered domains were therefor…
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