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BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments

Summary by Nature
The tumour-suppressor protein BRCA2 has a central role in homology-directed DNA repair by enhancing the formation of RAD51 filaments on resected single-stranded DNA generated at double-stranded DNA breaks and stimulating RAD51 activity1,2. Individuals with BRCA2 mutations are predisposed to cancer; however, BRCA2-deficient tumours are often responsive to targeted therapy with PARP inhibitors (PARPi)3–6. The mechanism by which BRCA2 deficiency re…

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BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments

The tumour-suppressor protein BRCA2 has a central role in homology-directed DNA repair by enhancing the formation of RAD51 filaments on resected single-stranded DNA generated at double-stranded DNA breaks and stimulating RAD51 activity1,2. Individuals with BRCA2 mutations are predisposed to cancer; however, BRCA2-deficient tumours are often responsive to targeted therapy with PARP inhibitors (PARPi)3–6. The mechanism by which BRCA2 deficiency re…

·United Kingdom
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portaldoriograndense.comportaldoriograndense.com

The Hidden Defense: How BRCA2 and an Overlooked Mechanism Could Transform Cancer Treatment

The BRCA2 gene is crucial for DNA repair and tumor suppression, with mutations increasing cancer risks. Researchers discovered a complex interaction among BRCA2, RAD51, and PARP1, vital for DNA repair. PARP inhibitors, intended for BRCA2-deficient cancers, might not work as expected due to this interaction. BRCA2 unexpectedly helps maintain DNA repair, potentially impacting the effectiveness of PARP inhibitors. This breakthrough offers new direc…

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BIOENGINEER.ORGBIOENGINEER.ORG

Leveraging Inherited Cancer Risk for Tailored Therapeutic Approaches

Mutations in the BRCA2 gene have long been implicated in a variety of cancers, including breast, ovarian, prostate, and pancreatic tumors. This gene plays a vital role in maintaining genomic stability by repairing DNA damage, a process essential for preventing uncontrolled cell growth. However, a recent study from Yale School of Medicine and New York University Grossman School of Medicine has shed new light on a protective mechanism associated w…

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MedscapeMedscape
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Anti-Aging, Acupuncture and Health NewsAnti-Aging, Acupuncture and Health News

Risk-Reduction Surgery Benefit in Non-BRCA Ovarian Cancer?

A comparison of patients with and without BRCA gene mutations receiving prophylactic risk-reduction surgery suggest questionable benefit of the surgery in patients with non-BRCA disease. Medscape Medical News

·United States
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targetedonc.comtargetedonc.com

Expanding HRD and BRCA1/2 Testing Could Improve Access to Effective Treatments in Ovarian and Breast Cancer

A real-world study reveals the need for increased homologous repair deficiency and BRCA1/2 testing in patients with ovarian and breast cancers.

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targetedonc.com broke the news in on Tuesday, March 25, 2025.
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