Targeting a Key Enzyme Could Reverse Early Parkinson's Effects

Targeting a key enzyme could reverse early Parkinson's effects

Putting the brakes on an enzyme might rescue neurons that are dying due to a type of Parkinson's disease that's caused by a single genetic mutation, according to a new Stanford Medicine-led study conducted in mice.

Inhibiting enzyme could halt cell death in Parkinson's disease, study finds

Putting the brakes on an enzyme might rescue neurons that are dying due to a type of Parkinson's disease that's caused by a single genetic mutation, according to a new Stanford Medicine-led study conducted in mice.

How Motor Symmetry Affects Parkinson’s Non-Motor Symptoms

In the landscape of neurodegenerative diseases, Parkinson’s disease (PD) stands as a formidable challenge to both clinicians and patients, with its multifaceted manifestations extending far beyond the well-characterized motor symptoms. A recent systematic review by Voruz, Guérin, and Péron, published in the renowned journal npj Parkinson’s Disease, casts new light on the intricate relationship between […]

Enzyme Inhibition Restores Neuron Pathways in a Parkinson's Mouse Model

In a new study published in Science Signaling titled, “Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson’s linked-LRRK2 mutant mice,” researchers from Stanford University and University of Dundee have shown that inhibition of a specific enzyme may rescue neurons that are dying due to a type of Parkinson’s disease that is caused by a single genetic mutation in a mouse model.  About 25% of Parkinson’s dise…