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Research reveals how psychedelics reshape communication between the brain and immune system

  • Dr. Michael Wheeler and his team published a Nature study on April 23, 2025, revealing that psychedelics reshape brain-immune communication to reduce fear and stress responses.
  • This research builds on findings that chronic stress disrupts amygdala signaling, triggering immune cell-driven inflammation that heightens fear behavior.
  • The study showed psychedelics block immune cells from accumulating in the brain, interrupting inflammatory cascades and lowering fear, supported by mouse models and human gene data.
  • The authors wrote, "psychedelic compounds can reverse this entire process," suggesting new treatment possibilities for depression and fear-based disorders.
  • These insights imply a paradigm shift in treating neuropsychiatric disorders by focusing on brain-immune interactions, but researchers caution psychedelics are not cure-alls and call for more study.
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DoubleBlind broke the news in on Monday, May 5, 2025.
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