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During aging, people with Down syndrome may face a higher risk of cardiovascular disease

  • The study evaluated cardiovascular disease risk with aging in a cohort of 5,155 individuals with Down syndrome from Sweden, born between 1946 and 2000, by comparing them to matched controls from the general population.
  • The study arose as longer life expectancy in Down syndrome reveals different age-related health risks and a distinct cardiovascular risk factor profile from the general population.
  • Researchers determined that individuals with Down syndrome have more than four times the likelihood of experiencing an ischemic stroke and over five times the likelihood of a hemorrhagic stroke compared to others. While the overall incidence of heart attacks is comparable to the general population, younger people with Down syndrome face a heightened risk.
  • Annie Pedersen, the lead author, noted that these findings may influence how healthcare providers monitor and manage cardiovascular health in people with Down syndrome as they age, reflecting changes in their risk for certain heart-related conditions.
  • The findings suggest caregivers should monitor stroke risk closely and promote healthy lifestyle habits, as stroke risk factors may include congenital heart disease, diabetes, obesity, and high cholesterol.
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Down Syndrome Patients Have Higher Stroke, Heart Attack Risk

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Medical Xpress broke the news in on Wednesday, May 7, 2025.
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