Drugs to stabilize CFTR protein region may help manage CF: Study

Drugs to stabilize CFTR protein region may help manage CF: Study

A lack of stability in a specific region of the CFTR protein may explain why certain people with cystic fibrosis (CF) don’t respond to available modulator therapies, a new study suggests. The findings imply drugs to stabilize this specific region — some of which are already in clinical development — may help manage CF in people who don’t respond to available therapies, researchers said. The study, “Proteostasis landscapes of cystic fibrosis vari…