Denver Broncos vs Indianapolis Colts Injury Report for NFL Week 2 Game: Colts Have Concerns at Cornerback
The Broncos must break their three-year streak of losing opening road games to secure a 2-0 start, relying on a top-ranked defense led by Patrick Surtain II.
- On Sunday, September 14, 2025, the Denver Broncos will visit the Indianapolis Colts for their Week 2 matchup, kicking off at 4:05 p.m. ET at Lucas Oil Stadium.
- The Colts begin the season 1-0 following a 33-8 victory over the Miami Dolphins but face challenges as cornerbacks Jaylon Jones and Charvarius Ward are expected to miss multiple games because of a hamstring injury and ongoing concussion protocol, respectively.
- The Broncos started their season 1-0 with a home victory over Tennessee, showcasing a stout defense that restricted the Titans to just 133 yards overall and forced two turnovers, despite the absence of key defensive players in practice.
- In Week 1, Broncos quarterback Bo Nix connected with Courtland Sutton for a touchdown but also threw a pair of interceptions, while Colts quarterback Daniel Jones gained over 250 passing yards and scored twice on the ground, setting the stage for a contest between Denver’s top-rated defense and Indianapolis’ dynamic offense.
- This game poses a significant challenge as the Colts work to safeguard a secondary impacted by injuries, while the Broncos aim to start 2-0 for the first time since 2021, with coach Sean Payton seeking one more victory to match Bill Parcells' total of 172 regular-season wins.
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Colts chase another milestone with 1st 2-0 start since 2009 in Week 2 matchup against the Broncos
Denver (1-0) at Indianapolis (1-0)Sunday, 4:05 p.m. EDT, CBSBetMGM NFL Odds: Colts by 2 1/2Against the spread: Broncos 0-0-1, Colts 1-0Series record: Tied 15-15Last meeting: Broncos beat Colts 31-13 on Dec. 15 in DenverLast week: Broncos beat Titans 20-12 at home; Colts beat Dolphins 33-8 at homeBroncos offense: overall (14T), rush (7), pass (21), scoring (15T)Broncos defense: overall (1), rush (8), pass (1), scoring (5)Colts offense: overall (4…

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Can The Colts Repeat Their Week 1 Performance Against Denver?
Source: Icon Sportswire / Getty The Indianapolis Colts kicked their 2025 season off in fantastic fashion, dominating the Miami Dolphins by the score of 33-8. Miami could just be a bad team on the fast track to a reboot, but it was still one of the most complete games the Colts have played in some time. Offensively, they could do almost no wrong, while defensively they had Mike McDaniel and the Miami offense completely confused. So was this a on…
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