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Denver Broncos vs Indianapolis Colts Injury Report for NFL Week 2 Game: Colts Have Concerns at Cornerback

The Broncos must break their three-year streak of losing opening road games to secure a 2-0 start, relying on a top-ranked defense led by Patrick Surtain II.

  • On Sunday, September 14, 2025, the Denver Broncos will visit the Indianapolis Colts for their Week 2 matchup, kicking off at 4:05 p.m. ET at Lucas Oil Stadium.
  • The Colts begin the season 1-0 following a 33-8 victory over the Miami Dolphins but face challenges as cornerbacks Jaylon Jones and Charvarius Ward are expected to miss multiple games because of a hamstring injury and ongoing concussion protocol, respectively.
  • The Broncos started their season 1-0 with a home victory over Tennessee, showcasing a stout defense that restricted the Titans to just 133 yards overall and forced two turnovers, despite the absence of key defensive players in practice.
  • In Week 1, Broncos quarterback Bo Nix connected with Courtland Sutton for a touchdown but also threw a pair of interceptions, while Colts quarterback Daniel Jones gained over 250 passing yards and scored twice on the ground, setting the stage for a contest between Denver’s top-rated defense and Indianapolis’ dynamic offense.
  • This game poses a significant challenge as the Colts work to safeguard a secondary impacted by injuries, while the Broncos aim to start 2-0 for the first time since 2021, with coach Sean Payton seeking one more victory to match Bill Parcells' total of 172 regular-season wins.
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DNVR broke the news in on Wednesday, September 10, 2025.
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