Abstract The aim of this study was to develop a once-daily controlled-release (CR) apixaban (APX) formulation that enhances bioavailability through dual mechanisms of P-glycoprotein (P-gp) inhibition and sustained drug release using selected functional pharmaceutical excipients. Based on the screening of pharmaceutical excipients with enhanced solubility and P-gp inhibitory properties for APX, CR formulations containing polyethylene oxide (PEO 1…
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