US EditionFloss-Based Vaccine Delivery Advances Toward Clinical Trials
NO LOC, JUL 29 – Researchers showed floss-based vaccine delivery triggered strong immune responses in mice and absorbed 60% of dye in human gums, indicating potential for needle-free immunization.
- Researchers unveiled on July 22, 2025 in Nature Biomedical Engineering that floss coated in vaccines triggers immune responses in mice.
- Years ago, Harvinder Gill, bioengineer at North Carolina State University, found the gingival sulcus absorbs molecules extremely well, inspiring the vaccine delivery concept.
- During a test run, researchers found that 75% of protein coated on floss was delivered to mouse gums and 60% of food dye reached volunteers’ gums.
- The testing found that the new technique stimulates mice to produce ample antibodies and immune cells, and all vaccinated mice survived while unvaccinated controls died.
- Such vaccines require no needles, refrigeration, or specialized training, and the next step is translating research to larger animals for human testing in the near future.
23 Articles
23 Articles
Dental Floss A Future Vaccine Delivery Method?
Scientists are developing another method of getting a vaccine into the human body. To create needle-free vaccines, researchers are experimenting with a special type of dental floss that can deliver “proteins and inactive viruses,” Science reports. There’s nothing that won’t be attempted to give people a vaccine. For now, scientists are experimenting on mice’s gumlines to trigger immune responses. Scientists have figured out how to turn dental f…
Why you may get future vaccines via dental floss
Researchers have demonstrated a novel vaccine delivery method in an animal model, using dental floss to introduce the vaccine via the tissue between the teeth and gums. The testing found that the new technique stimulates the production of antibodies in mucosal surfaces, such as the lining of the nose and lungs.
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