Scientists discover new inhibitors of inflammation-related enzyme

Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults

Slow paced breathing via heart rate variability (HRV) biofeedback stimulates vagus-nerve pathways that counter noradrenergic stress and arousal pathways that can influence production and clearance of Alzheimer's disease (AD)-related proteins. Thus, we examined whether HRV biofeedback intervention affects plasma Αβ40, Αβ42, total tau (tTau), and phosphorylated tau-181 (pTau-181) levels. We randomized healthy adults (N = 108) to use slow-paced bre…

Scientists discover new inhibitors of inflammation-related enzyme

Using computational tools and virtual screening, researchers at the Center for Redox Processes in Biomedicine (Redoxoma) have identified new inhibitors of the enzyme human 15-lipoxygenase-2 (h15-LOX-2). This protein plays an important role in inflammatory and metabolic processes and contributes to cellular homeostasis.

Inflammatory messenger fuels Alzheimer's

Researchers have detailed the precise mechanism through which the inflammatory signaling molecule IL-12 contributes to Alzheimer's disease.

Famous American cardiologist of Indian descent, Sandeep Jauhar publishes medical outreach articles in The New York Times with assiduousness and, like so many essayists and columnists, communicates to his readers with the most natural nature the interiorities not of his thought, but of his private life. In his book The Brain of My Father, which is now published in Spanish, opens our hearts to relate in detail the process of senile dementia that a…

Microglia's inflammatory shift: How IL-12 accelerates Alzheimer's damage

Microglia, the brain's immune cells, usually serve as diligent guardians. They eliminate intruders such as microbes and clear away cellular debris—including the plaques typical of Alzheimer's disease. However, as our brains age, microglia also change. While some continue to function effectively, others gradually lose their protective role and start secreting small amounts of inflammatory messengers.

Research Into a COVID-Alzheimer's Link Continues

When the COVID-19 pandemic hit in 2019, researchers raised concerns it would increase the risk of neurodegenerative diseases like Alzheimer’s and Parkinson’s.  A recent... The post Research Into a COVID-Alzheimer’s Link Continues appeared first on Being Patient.