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'The Sopranos' Creator David Chase Returning to TV with New Show About Cold War Mind Control Experiements

The series will dramatize CIA's MKUltra Cold War mind control experiments led by Sidney Gottlieb, based on John Lisle's nonfiction book, in development at HBO.

  • HBO is developing a limited series titled Project: MKUltra from David Chase, who optioned John Lisle's nonfiction book and will write the adaptation under his Riverain Pictures first-look deal.
  • Centered on Sidney Gottlieb, the series examines the CIA's MKUltra program, which conducted psychedelic and mind-control experiments on willing and unwilling subjects during the Cold War.
  • A seven-time Emmy winner, Chase returns to television with this project, his first series since The Sopranos, which ran six seasons on HBO from 1999 to 2007.
  • Chase and Nicole Lambert will executive produce Project: MKUltra through Riverain Pictures, where Lambert is Head of Production and Development, and Deadline first reported the news.
  • Chase plans to shoot an indie movie early next year and previously sold a witness protection project to FX based on an unproduced script but exited due to schedule conflicts.
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Deadline broke the news in Los Angeles, United States on Wednesday, October 22, 2025.
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